Indole, the bicyclic ring system consists of pyrrole ring fused with benzene ring. Although indole moiety is very small but is fascinated by scientists because of the diverse biological activities by not only indole but its various substituted derivatives as well. In the present study some novel indole carboxamide derivatives like 6-Chloro-3-[(N,N-diethylamino)(oxo)acetyl]-1-methyl-N-aryl-1H-indole-5-carboxamide derivatives (IC-1 to IC-10) were synthesized according to the scheme. From all the synthesized novel indole carboxamide derivatives, IC-1 and IC-2 has been characterized by using elemental analysis, FT-IR, 1HNMR, 13C NMR spectroscopy and further supported by mass spectroscopy remaining are characterized by using elemental analysis, FT-IR, further supported by mass spectroscopy. Purity of all the compounds has been checked on thin layer chromatographic plate and HPLC technique. All the synthesized compounds were evaluated for in-vivo diuretic activity by collecting total excreted urine (0-5 hrs) of rat kept in metabolic cage. All the compounds exhibited moderate to significant diuretic activity.
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